Table 1 Baseline characteristics
From: Differential response to donepezil in MRI subtypes of mild cognitive impairment
Placebo (n = 90) | Donepezil (n = 83) | p value | |
|---|---|---|---|
Age, | 73.7 (6.6) | 73.9 (6.6) | 0.595 |
Sex, female, n (%) | 45 (53) | 44 (51) | 0.866 |
Education, n (%) | 0.213 | ||
No education | 0 (0) | 1 (1) | - |
Primary | 7 (8) | 6 (7) | - |
Certification of primary | 31 (37) | 42 (47) | - |
Secondary | 23 (28) | 13 (15) | - |
Higher education | 22 (27) | 27 (30) | - |
Duration of memory disorders | 39.0 (28.6) | 31.8 (24.7) | 0.079 |
Hamilton Depression Rating Scale | 3.2 (3.0) | 2.8 (2.5) | 0.807 |
APOE ε4 carriers, n (%) a | 16/28 (57) | 16/36 (44) | 0.450 |
Follow-up MRI (months) | 11.5 (1.6) | 11.7 (1.2) | 0.746 |
MMSE | 25.8 (2.6) | 26.2 (2.1) | 0.359 |
ADAS-COG-MCI | 12.1 (4.2) | 12.0 (4.3) | 0.835 |
TMT-A (Time) | 63.4 (31.1) | 61.4 (26.9) | 0.857 |
TMT-B (Time) | 156.8 (65.5) | 143.7 (58.1) | 0.238 |
Benton test | 6.9 (2.0) | 7.1 (1.9) | 0.439 |
Isaacs test (15 items) | 24.7 (5.2) | 25.0 (5.2) | 0.692 |
Isaacs test (60 items) | 49.8 (10.8) | 50.0 (12.8) | 0.818 |
Field strength 3 T, n (%) | 22 (25) | 23 (28) | 0.785 |
Total hippocampal volume | 6270.1 (904.8) | 6275.3 (807.2) | 0.851 |
Total grey matter volume | 549,962.0 (29,424.3) | 554,866.0 (32,668.1) | 0.300 |
Lateral ventricular volume | 36,435.5 (14,131.3) | 36,838.3 (15,357.9) | 0.925 |
AD signature thickness | 2.6 (0.2) | 2.7 (0.9) | 0.516 |
BV/CSF index | 28.9 (12.9) | 29.4 (12.6) | 0.884 |
Hippocampus-to-cortex ratiob | 0.1 (0.01) | 0.1 (0.01) | 0.139 |