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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia

Fig. 1

Negative influence of white matter hyperintensity load on voxel-wise grey matter volume in cognitively unimpaired and early-stage dementia participants. In both cognitively unimpaired (A) and early dementia participants (B), increasing WMH load was associated with lower voxel-wise GMV across frontal, parietal, temporal, and occipital regions. Clusters showing GMV loss related to WMH are shown in red. There were no positive associations between WMH load and voxel-wise GMV. Results are shown at the uncorrected p < 0.001 height threshold with an extent threshold of 100 voxels. Results are displayed on representative sections of the MNI template brain. WMH, white matter hyperintensity; GMV, grey matter volume

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Alzheimer's Research & Therapy

ISSN: 1758-9193