Genetic risk for dementia | Cases/Population | Age and sex adjusted HR (95% CI) | p-value for interaction | Fully adjusteda HR (95% CI) | p-value for interaction |
---|---|---|---|---|---|
Dementia non-APOE PRS | |||||
 Low | |||||
   ≥ 90 | 184/10,607 | 1 (Reference) |  | 1 (Reference) |  |
  60–89 | 491/21,127 | 1.11 (0.94–1.32) |  | 1.07 (0.90–1.27) |  |
   < 60 | 58/1,521 | 1.72 (1.28–2.31) |  | 1.43 (1.06–1.92) |  |
 Intermediate | |||||
   ≥ 90 | 762/31,517 | 1 (Reference) |  | 1 (Reference) |  |
  60–89 | 1,846/63,585 | 1.01 (0.92–1.10) |  | 1.00 (0.92–1.09) |  |
   < 60 | 259/4,663 | 1.80 (1.56–2.08) |  | 1.58 (1.37–1.83) |  |
 High | |||||
   ≥ 90 | 341/10,641 | 1 (Reference) |  | 1 (Reference) |  |
  60–89 | 877/21,087 | 1.07 (0.95–1.22) |  | 1.08 (0.95–1.23) |  |
   < 60 | 95/1,526 | 1.60 (1.27–2.01) | 0.48 | 1.39 (1.10–1.74) | 0.42 |
APOE allele | |||||
 ε3/ε3 | |||||
   ≥ 90 | 595/37,092 | 1 (Reference) |  | 1 (Reference) |  |
  60–89 | 1,494/75,296 | 1.02 (0.93–1.13) |  | 1.00 (0.90–1.10) |  |
   < 60 | 211/5,657 | 1.81 (1.54–2.12) |  | 1.50 (1.28–1.76) |  |
 ε4/ε4 or ε3/ε4 | |||||
   ≥ 90 | 874/16,962 | 1 (Reference) |  | 1 (Reference) |  |
  60–89 | 1,990/32,298 | 1.01 (0.93–1.09) |  | 0.98 (0.91–1.07) |  |
   < 60 | 215/2,227 | 1.53 (1.32–1.78) |  | 1.27 (1.09–1.48) |  |
 ε2/ε2 or ε3/ε2 | |||||
   ≥ 90 | 83/7,721 | 1 (Reference) |  | 1 (Reference) |  |
  60–89 | 288/16,984 | 1.32 (1.03–1.68) |  | 1.28 (1.00–1.64) |  |
   < 60 | 49/1,306 | 2.71 (1.90–3.86) | 0.04 | 2.25 (1.58–3.20) | 0.04 |