Table 4 Lead variants for PD or ALS associated with both disorders at a family-wise error rate of 5%. A1 = effect allele; A2 = non-effect allele; OR = odds ratio; PPshared/distinct = posterior probability that the two disorders share the same causal variant/have two distinct causal variants at the locus according to colocalization analysis
Locus | Variant | A1/A2 | Lead for | PD | ALS | PPshared | PPdistinct | Nearest gene | Most evidence for | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
OR | p-value | OR | p-value | ||||||||
1 | rs873786 | T/C | PD | 0.84 | 1.8 × 10−21 | 0.89 | 1.3 × 10−7 | 98.3% | 1.6% | GAK | GAK, TMEM175 |
1 | rs34311866 | T/C | PD | 0.81 | 1.0 × 10−69 | 0.93 | 1.1 × 10−6 | 98.3% | 1.6% | TMEM175 | GAK, TMEM175 |
2 | rs62333164 | A/G | Both | 0.94 | 2.0 × 10−10 | 1.07 | 6.9 × 10−9 | 98.9% | 1.1% | CLCN3 | NEK1 |