Table 3 Lead variants for ADRD or ALS associated with both disorders at a family-wise error rate of 5%. Odds ratios and p-values for AD (from Kunkle et al.) are also included as a sensitivity analysis. A1 = effect allele; A2 = non-effect allele; OR = odds ratio; PPshared/distinct = posterior probability that the two disorders share the same causal variant/have two distinct causal variants at the locus according to colocalization analysis. For ADRD, odds ratios and p-values are from the full 788,989 participants where available (i.e., for ADRD lead variants) and from the 487,511 participants with genome-wide summary statistics otherwise (i.e., for the ALS lead variant)
Locus | Variant | A1/A2 | Lead for | AD | ADRD | ALS | PPshared | PPdistinct | Nearest gene | Most evidence for | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR | p-value | OR | p-value | OR | p-value | ||||||||
1 | rs871269 | T/C | ADRD | 0.97 | 0.068 | 0.96 | 8.7 × 10−9 | 0.95 | 6.8 × 10−6 | 0.9% | 30.1% | TNIP1 | GPX3 |
2 | rs785129 | T/C | ADRD | 1.04 | 0.017 | 1.04 | 2.4 × 10−9 | 1.05 | 4.3 × 10−5 | 12.0% | 84.0% | HS3ST5 | HS3ST5, HDAC2, MARCKS |
3 | rs199515 | C/G | ADRD | 1.05 | 0.011 | 1.06 | 9.3 × 10−13 | 1.05 | 1.2 × 10−4 | 26.0% | 63.9% | WNT3 | MAPT, KANSL1 |
4 | rs2526377 | A/G | ADRD | 1.07 | 2.0 × 10−6 | 1.05 | 1.6 × 10−12 | 1.04 | 1.0 × 10−4 | 73.9% | 5.9% | TSPOAP1 | TSPOAP1 |