Table 2 Lead variants for ADRD or PD associated with both disorders at a family-wise error rate of 5%. Odds ratios and p-values for AD (from Kunkle et al.) are also included as a sensitivity analysis. A1 = effect allele; A2 = non-effect allele; OR = odds ratio; PPshared/distinct = posterior probability that the two disorders share the same causal variant/have two distinct causal variants at the locus according to colocalization analysis. rs199526 was chosen as an LD proxy (r2 = 0.911 in TopLD) of the true ADRD lead variant, rs199515, which was not available in the PD summary statistics. For ADRD, odds ratios and p-values are from the full 788,989 participants where available (i.e., for ADRD lead variants, aside from the LD proxy rs199526) and from the 487,511 participants with genome-wide summary statistics otherwise (i.e., for the PD lead variants and rs199526)
Locus | Variant | A1/A2 | Lead for | AD | ADRD | PD | PPshared | PPdistinct | Nearest gene | Most evidence for | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR | p-value | OR | p-value | OR | p-value | ||||||||
1 | rs34025766 | A/T | PD | 1.04 | 0.04 | 1.04 | 2.5 × 10−4 | 0.98 | 2.9 × 10−10 | 65.3% | 16.6% | LCORL | Unclear |
2 | rs11787077 | T/C | ADRD | 0.88 | 2.5 × 10−16 | 0.91 | 1.7 × 10−44 | 0.96 | 1.7 × 10−4 | 88.4% | 1.8% | CLU | CLU |
3 | rs11150601 | A/G | PD | 1.04 | 0.0067 | 1.03 | 1.5 × 10−4 | 1.09 | 5.1 × 10−20 | 0.0% | 100.0% | SETD1A | SETD1A, KAT8 |
3 | rs889555 | T/C | ADRD | 0.96 | 0.0056 | 0.95 | 2.0 × 10−11 | 0.94 | 5.6 × 10−9 | 0.0% | 100.0% | BCKDK | SETD1A, KAT8 |
4 | rs450674 | T/C | ADRD | 1.03 | 0.038 | 1.04 | 3.2 × 10−8 | 1.04 | 2.1 × 10−4 | 80.5% | 9.8% | MAF | WWOX |
5 | rs5848 | T/C | ADRD | 1.05 | 0.0029 | 1.07 | 2.4 × 10−20 | 1.07 | 1.8 × 10−12 | 25.8% | 74.2% | GRN | GRN |
5 | rs850738 | A/G | PD | 0.97 | 0.035 | 0.96 | 3.0 × 10−6 | 0.93 | 1.3 × 10−11 | 25.8% | 74.2% | FAM171A2 | GRN |
6 | rs62053943 | T/C | PD | 0.94 | 0.0097 | 0.95 | 5.1 × 10−6 | 0.76 | 3.6 × 10−68 | 18.4% | 81.6% | LINC02210-CRHR1 | MAPT, KANSL1 |
6 | rs199526 | C/G | ADRD | 0.96 | 0.014 | 0.95 | 1.7 × 10−8 | 0.81 | 1.8 × 10−65 | 18.4% | 81.6% | WNT3 | MAPT, KANSL1 |