Table 1 Genetic correlations between AD/ADRD, PD, and ALS according to three genetic correlation methods. Tabular version of Fig. 1. Square brackets indicate 95% confidence intervals. For comparison, genetic correlations calculated from a previous study [43] are also shown. Wingo et al. used an older ADRD GWAS (Jansen et al. 2019 [44] instead of Bellenguez et al. 2022 [22]) and used a version of the summary statistics from Nalls et al. 2019 [29]  that did not include 23andMe participants

AD, PD

0.02 [−0.11, 0.15] (p = 0.75)

 −0.03 [−0.14, 0.08] (p = 0.58)

 −0.03 [−0.10, 0.05] (p = 0.46)

0.07 [−0.09, 0.23] (p = 0.35)

ADRD, PD

0.14 [0.05, 0.24] (p = 0.0032)

0.13 [0.04, 0.23] (p = 0.0054)

0.11 [0.04, 0.19] (p = 0.0042)

0.16 [0.04, 0.28] (p = 0.0055)

AD, ALS

0.21 [0.08, 0.34] (p = 0.0018)

0.27 [0.13, 0.42] (p = 1.8 × 10⁻⁴)

0.16 [0.07, 0.25] (p = 7.5 × 10⁻⁴)

0.17 [−0.07, 0.41] (p = 0.17)

ADRD, ALS

0.25 [0.15, 0.35] (p = 1.3 × 10⁻⁶)

0.22 [0.11, 0.33] (p = 6.3 × 10⁻⁵)

0.16 [0.08, 0.24] (p = 5.5 × 10⁻⁵)

0.21 [−0.01, 0.43] (p = 0.046)

PD, ALS

0.09 [−0.00, 0.19] (p = 0.059)

0.11 [0.03, 0.20] (p = 0.0085)

0.07 [0.01, 0.14] (p = 0.031)

0.06 [−0.12, 0.24] (p = 0.52)