Table 3 Top unique significant Gene Ontology terms stratified for APOE4 or amyloid positivity status at follow-up compared to baseline

Up

GO:0,005,759 (CC)

Mitochondrial matrix

7.3 × 10⁻⁷

-

-

-

-

GO:0,006,091 (BP)

Generation of precursor metabolites and energy

8.5 × 10⁻⁴

-

-

-

-

GO:0,032,543 (BP)

Mitochondrial translation

1.0 × 10⁻³

-

-

-

-

GO:0,005,689 (CC)

U12-type spliceosomal complex

1.4 × 10⁻³

-

-

-

-

GO:0,006,457 (CC)

Protein folding

2.0 × 10⁻³

-

-

-

-

Down

GO:0,099,537 (BP)

Trans-synaptic signalling

1.1 × 10⁻⁵

GO:0,110,020 (BP)

Regulation of actomyosin structure organisation

8.1 × 10⁻⁵

 − 1.99

GO:0,099,177 (BP)

Regulation of trans-synaptic signalling

2.3 × 10⁻⁴

GO:0,032,231 (BP)

Regulation of actin filament bundle assembly

1.2 × 10⁻⁴

 − 1.95

GO:0,016,323 (CC)

Basolateral plasma membrane

2.4 × 10⁻⁴

GO:0,051,492 (BP)

Regulation of stress fibre assembly

1.3 × 10⁻⁴

 − 1.97

GO:0,099,003 (BP)

Vesicle-mediated transport in synapse

7.1 × 10⁻⁴

GO:0,046,939 (BP)

Nucleotide phosphorylation

2.8 × 10⁻⁴

 − 1.86

GO:0,042,581 (CC)

Specific granule

8.0 × 10⁻⁴

GO:0,006,165 (BP)

Nucleoside diphosphate phosphorylation

4.7 × 10⁻⁴

 − 1.88

Amyloid negative–positive and amyloid-positive

Amyloid negative-negative

Up

GO:0,046,034 (BP)

ATP metabolic process

6.5 × 10⁻³

GO:0,071,013 (CC)

Catalytic step 2 spliceosome

7.8 × 10⁻³

1.66

GO:0,005,925 (CC)

Focal adhesion

6.5 × 10⁻³

-

-

-

-

GO:0,030,055 (CC)

Cell-substrate junction

9.91 × 10⁻³

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Down

-

-

-

GO:0,014,855 (BP)

Striated muscle cell proliferation

6.81 × 10⁻³

 − 1.80

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-