Fig. 2

Differentially expressed genes at follow-up compared to baseline stratified for APOE4 or amyloid positivity status. A Volcano plot showing the differentially expressed genes at follow-up compared to baseline in APOE4 carriers. B Volcano plot showing the differentially expressed genes at follow-up compared to baseline in APOE4 non-carriers. C Volcano plot showing the differentially expressed genes at follow-up compared to baseline in individuals amyloid positive at both time points or amyloid negative at baseline, positive at follow-up. D Volcano plot showing the differentially expressed genes at follow-up compared to baseline in individuals amyloid negative at both time points. Data points are coloured based on significance: grey = non-significant, blue = non-significant but with p_FDR-value < 0.05, red = significant with p_FDR-value < 0.05 and log2FoldChange ± 1. APOE4 carriers N = 31, APOE4 non-carriers N = 34. Amyloid positive-positive or amyloid negative–positive N = 9, amyloid negative-negative N = 56