Table 1 Demographic and clinical data

Age

65.36 ± 5.80

64.40 ± 5.49

65.18 ± 5.90

65.87 ± 5.80

0.382

0.766

Sex (male/female)

14/63

7/33

7/33

4/19

0.015

1.000

Education years

12.86 ± 2.97

12.68 ± 2.64

11.79 ± 2.36

12.65 ± 3.61

1.272

0.286

MRI (TX/CX)

30/47

13/27

17/23

9/14

0.889

0.828

SCD-Q

3.90 ± 1.99

5.68 ± 1.29^a

5.81 ± 1.25^b

5.20 ± 2.07^c

15.395

< 0.001*

MMSE

28.73 ± 1.19

28.75 ± 1.28

28.43 ± 1.53

27.26 ± 3.55^cef

4.564

0.004*

Composite Z scores of each cognitive domain

 Memory function

0.29 ± 0.78

0.10 ± 0.71

− 0.11 ± 0.78^b

− 0.97 ± 0.73^cef

16.872

< 0.001*

 Language function

0.21 ± 0.82

0.24 ± 0.63

− 0.31 ± 0.79^bd

− 0.59 ± 0.70^ce

9.931

< 0.001*

 Executive function

0.10 ± 0.60

0.28 ± 0.64

− 0.15 ± 0.65^bd

− 0.56 ± 0.63^cef

10.284

< 0.001*

 Navigation distance errors

− 0.28 ± 0.65

− 0.51 ± 0.27

0.80 ± 0.69^bd

0.42 ± 1.03^cef

35.129

< 0.001*

 TIV

0.05 ± 0.99

0.11 ± 0.90

− 0.09 ± 1.07

− 0.21 ± 1.10

0.674

0.569

 IQR (%)

84.50 ± 1.93

84.69 ± 1.79

84.59 ± 1.73

84.93 ± 1.46

0.373

0.773