Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer’s disease

Table 3 Results of EWAS meta-analysis using AD case–control status

CpG	Position	Genes	p-value	Effect (β)	Previous Studies (ref.)^a
cg03169557	chr16:89,598,950	RPL13, SPG7	6.59E-09	0.0214	[8, 16,17,18]
cg05066959	chr8:41,519,308	NKX6-3, ANK1, MIR486	1.30E-08	0.0453	[6, 8, 9, 16,17,18]
cg03073402	chr19:42,927,676	CNFN, LIPE	5.59E-08	-0.0086	-
cg22388948	chr6:82,460,558	TENT5A	5.83E-08	-0.0270	-
cg20648333	chr10:72,298,745	PALD1, PRF1	1.44E-07	-0.0183	-

Experiment-wide significant CpGs (p < 1.64E-07) in the meta-EWAS ascross three datasets (London-1, London-2, Oxford) using AD case–control status
^aEvidence for implication of same or largely overlapping locus from studies using DNAm assessments in AD-related phenotypes. Annotation of CpGs to specific gene regions was based on the Illumina manifest (v1.0 B5) for the EPIC array and the GREAT annotation tool [28]

ISSN: 1758-9193