Table 1 Demographic (age, YECO, sex, and years of education) and basic clinical characteristics of patients with MCI or sAD subdivided according to amyloid abnormality (yes or no). P-values of two-way (diagnostic group and amyloid abnormality) ANOVAs

N (% females)

25 (56)

21 (62)

42 (57)

6 (33)

ns

ns

ns

Age, years

65.0 ± 7.5

63.1 ± 8.1

67.0 ± 8.7

65.4 ± 8.3

ns

ns

ns

Education, years

13.3 ± 3.5

12.4 ± 3.2

12.4 ± 3.8

12.7 ± 4.0

ns

ns

ns

YECO, years

 − 1.2 ± 4.4

 − 5.5 ± 5.6

 + 3.8 ± 4.6

 + 0.5 ± 5.8

***

**

ns

MMSE, score

27.5 ± 2.2

27.7 ± 2.7

24.6 ± 3.6

26.2 ± 2.7

**

ns

ns

APOE e4 + , n (%)

0.87 ± 0.82

0.70 ± 0.66

1.12 ± 0.78

1.33 ± 0.82

*

ns

ns

CSF Aβ₄₂

569 ± 161

724 ± 285

418 ± 135

399 ± 122

***

ns

ns

CSF total-tau

455 ± 157

325 ± 185

615 ± 266

474 ± 333

*

*

ns

CSF p-tau

75.3 ± 23.0

56.5 ± 22.7

89.0 ± 31.2

63.0 ± 0.0

ns

ns

ns