Table 1 Characteristics of the study population
Overall population | Missing | A/T/N profiles | ||||||
|---|---|---|---|---|---|---|---|---|
A − /T − /N − | A − /T − /N + | A − /T + | A + /T − | A + /T + | ||||
N = 1353 | N (%) | N = 418 | N = 56 | N = 162 | N = 214 | N = 503 | p value | |
Age, mean (SD) | 68.2 (9.8) | 0 | 63.8 (10.9) | 66.1 (9.1) | 70.7 (8.2) | 69.5 (9.4) | 70.6 (8.3) | < 0.001 |
Women, n (%) | 722 (53.4) | 0 | 193 (46.2) | 33 (58.9) | 84 (51.9) | 109 (50.9) | 303 (60.2) | < 0.001 |
Education level, n (%) | ||||||||
Low | 370 (27.4) | 103 (24.6) | 9 (16.1) | 47 (29.0) | 64 (29.9) | 147 (29.2) | ||
Intermediate | 455 (33.6) | 146 (34.9) | 20 (35.7) | 57 (35.2) | 70 (32.7) | 162 (32.2) | ||
High | 528 (39.0) | 169 (40.4) | 27 (48.2) | 58 (35.8) | 80 (37.4) | 194 (38.6) | 0.45 | |
MMSE score, mean (SD) | 22.6 (5.4) | 0 | 24.5 (4.1) | 23.3 (5.8) | 23.8 (4.4) | 21.6 (6.1) | 21.0 (5.8) | < 0.001 |
Cognitive stage, n (%) | ||||||||
Cognitively unimpaired | 362 (26.8) | 155 (37.1) | 17 (30.4) | 53 (32.7) | 55 (25.7) | 82 (16.3) | ||
Mild cognitive impairment | 538 (39.8) | 184 (44.0) | 26 (46.4) | 66 (40.7) | 73 (34.1) | 189 (37.6) | ||
Dementia | 453 (33.5) | 79 (18.9) | 13 (23.2) | 43 (26.5) | 86 (40.2) | 232 (46.1) | < 0.001 | |
APOE4 carriers, n (%) | 511 (42.4) | 148 (10.9%) | 75 (20.3) | 11 (22.9) | 51 (33.3) | 100 (55.0) | 274 (60.5) | < 0.001 |
Heavy alcohol consumption,a n (%) | 87 (7.6) | 215 (15.9%) | 36 (10.3) | 4 (8.9) | 7 (5.2) | 11 (6.3) | 29 (6.7) | 0.40 |
Smokers, n (%) | 123 (10.5) | 183 (13.5%) | 41 (11.2) | 8 (17.0) | 12 (8.7) | 20 (11.1) | 42 (9.6) | 0.51 |
Dyslipidemia, n (%) | 387 (31.3) | 115 (8.5%) | 107 (28.1) | 13 (26.5) | 56 (37.3) | 52 (27.7) | 159 (33.8) | 0.11 |
Hypertension, n (%) | 562 (45.2) | 102 (7.5%) | 157 (40.7) | 19 (38.8) | 74 (50.0) | 84 (44.4) | 228 (48.3) | 0.12 |
Diabetes mellitus, n (%) | 191 (15.4) | 114 (8.4%) | 67 (17.5) | 8 (16.3) | 26 (17.3) | 23 (12.2) | 67 (14.3) | 0.45 |