Table 3 Diagnostic value of the CSF biomarkers

Core biomarker

AUC

P-value

AUC

P-value

AUC

P-value

 Aβ42

1.00 (1.00, 1.00)

 < 0.001

0.66 (0.48, 0.84)

0.079

0.92 (0.83, 1.00)

 < 0.001

 Tau

0.98 (0.99, 1.00)

 < 0.001

0.87 (0.74, 0.99)

 < 0.001

0.82 (0.69, 0.96)

 < 0.001

 PTau

1.00 (1.00, 1.00)

 < 0.001

0.81 (0.67, 0.94)

0.001

0.83 (0.69, 0.96)

 < 0.001

 NfL

0.88 (0.76, 0.99)

 < 0.001

0.98 (0.95, 1.00)

 < 0.001

0.88 (0.75, 1.00)

 < 0.001

Synaptic biomarker

AUC

P-value

AUC

P-value

AUC

P-value

 SNAP25

0.99 (0.96, 1.00)

 < 0.001

0.83 (0.70, 0.96)

 < 0.001

0.75 (0.58, 0.89)

0.007

 VAMP2

0.82 (0.69, 0.95)

 < 0.001

0.77 (0.62, 0.92)

0.003

0.50 (0.31, 0.69)

0.978

 Ng

0.87 (0.77, 0.98)

 < 0.001

0.79 (0.64, 0.93)

0.002

0.65 (0.48, 0.82)

0.110

 NPTX2

0.62 (0.45, 0.79)

0.185

0.70 (0.54, 0.87)

0.028

0.57 (0.39, 0.76)

0.402

 GluR4

0.60 (0.42, 0.78)

0.291

0.51 (0.32, 0.69)

0.935

0.60 (0.42, 0.78)

0.267

 Selected panel

0.99 (0.96, 1.00)

 < 0.001

0.97 (0.93, 1.00)

 < 0.001

0.84 (0.70, 0.98)

 < 0.001