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Table 2 Regional 11C-PiB SUVR values for APOE ε4 homozygotes, heterozygotes, and non-carriers

From: APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly

Region

11C-PiB binding (SUVR)

 

ε4ε4 vs ε3ε3

ε4ε4 vs ε4ε3

ε4ε3 vs ε3ε3

APOEε4ε4

APOEε4ε3

APOEε3ε3

Pa

Pb

Pb

Pb

Prefrontal cortex

2.23 (1.65–2.89)

1.51 (1.40–1.99)

1.43 (1.35–1.65)

0.0007

0.0007

0.023

0.84

Parietal cortex

2.34 (1.71–2.79)

1.70 (1.48–2.21)

1.56 (1.47–1.75)

0.0098

0.011

0.071

1.00

Anterior cingulum

2.42 (1.70–3.04)

1.73 (1.54–2.20)

1.56 (1.47–1.73)

0.0007

0.0005

0.064

0.37

Posterior cingulum

2.43 (1.74–3.15)

1.76 (1.59–2.23)

1.64 (1.57–1.89)

0.016

0.017

0.12

1.00

Precuneus

2.84 (1.80–3.23)

1.79 (1.57–2.49)

1.68 (1.60–1.91)

0.0041

0.004

0.057

1.00

Lateral temporal cortex

1.78 (1.49–2.50)

1.44 (1.30–1.67)

1.35 (1.28–1.50)

0.0053

0.0043

0.11

0.77

Cortical composite

2.13 (1.61–2.83)

1.55 (1.43–2.02)

1.47 (1.38–1.66)

0.0024

0.002

0.056

0.82

  1. Data presented as median (interquartile range)
  2. Pa, Kruskal–Wallis test; Pb, Dunn's method for pairwise comparisons