Fig. 2
Mean 11C-PiB and 11C-PK11195 distribution maps and regional ligand-binding in cognitively unimpaired volunteers stratified by APOE ε4 gene dose. A Mean 11C-PiB standardized uptake value ratio (SUVR) distribution maps and B region-of-interest analysis showed significantly higher uptake in APOE ε4 homozygotes compared with non-carriers in all evaluated regions and compared with heterozygotes in anterior cingulate and prefrontal cortex (Kruskal–Wallis test with Dunn's method for multiple comparisons). C Mean11C-PK11195 standardized distribution volume ratio (DVR) maps showed regional differences in tracer-binding, D but no significant differences between the APOE ε4 gene dose groups (one-way ANOVA with Tukey’s honest significance test for multiple comparisons). ACIN, anterior cingulate; HIP, hippocampus; LTC, lateral temporal cortex; PFC, prefrontal cortex, PARC, parietal cortex; PCIN, posterior cingulate cortex; PREC, precuneus. * P < 0.05; ** P < 0.01; *** P < 0.001