Fig. 5

Relationships between subcortical fractional anisotropy and subcortical mean diffusivity with the CDR® plus NACC FTLD-SB scores. Correlations of subcortical fractional anisotropy (left) and subcortical (right) with CDR® plus NACC FTLD-SB scores in each FTLD subgroup. Regions of lower fractional anisotropy associated with higher CDR® plus NACC FTLD-SB scores (blue-light blue) were found in the bvFTD, nfvPPA, and svPPA patients, whereas regions of increased mean diffusivity related to increases in CDR® plus NACC FTLD-SB scores (red–orange) were found in each subgroup. The results have been overlaid on a skull-stripped MNI152 template. bvFTD, behavioral variant of frontotemporal dementia; BNT, boston naming test; CDR® plus NACC FTLD-SB, clinical dementia rating plus national Alzheimer’s coordinating center behavior and language domains sum of boxes; FTLD, frontotemporal lobar degeneration; nfvPPA, nonfluent variant primary progressive aphasia; svPPA, semantic variant primary progressive aphasia; VFT, verbal fluency test