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Fig. 8 | Alzheimer's Research & Therapy

Fig. 8

From: Clusters of co-abundant proteins in the brain cortex associated with fronto-temporal lobar degeneration

Fig. 8

Cell type enrichment in modules A M03 (postsynapse organisation), B M04 (oxidative phosphorylation), C M06 (vesicle-mediated transport), and D M10 (phenylalanine-tRNA ligase activity). Cell type enrichment in each of the modules was determined based on the log2FC values of specific CNS cell-type protein markers (shown here for the temporal validation set). Included cell types are astrocytes, endothelial cells, excitatory neurons, inhibitory neurons, microglia, oligodendrocytes, and oligodendrocyte precursor cells. Enrichment up (red bar) means that the markers for that cell type had high log2FC values in the FTLD-tau samples compared to the control group, and enrichment down (blue bar) means that the markers for that cell type had low log2FC values in the FTLD-tau samples compared to the control group

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Alzheimer's Research & Therapy

ISSN: 1758-9193