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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Clusters of co-abundant proteins in the brain cortex associated with fronto-temporal lobar degeneration

Fig. 1

Overview of the workflow. Tissue sections of fresh frozen medial frontal gyrus were microdissected to isolate the cortex. Proteins were quantified using LC-MS/MS. Differentially expressed proteins were identified by comparing protein abundance levels across the 3 diagnostic groups. GSEA was performed to identify the classes of proteins enriched in FTLD-tau and/or FTLD-TDP. WGCNA was performed to identify the modules of co-regulated proteins. Based on these modules, cell-type enrichment analysis was performed to identify the cell type most significantly associated with the protein modules. Finally, modules were validated using 2 validation data sets (frontal validation data set and temporal validation data set)

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Alzheimer's Research & Therapy

ISSN: 1758-9193