Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the AppNL−F/NL−F knock-in mouse model of Alzheimer’s disease

Table 1 Correlations between the Aβ42/Aβ40 ratio in CSF and serum and cerebral Aβ pathology in App^{NL−F/NL−F} knock-in mice

	CSF Aβ42/Aβ40 ratio	Serum Aβ42/Aβ40 ratio	Meng’s Z-test (p-value)
Cortical Aβ42 (%Area)	r_s = − 0.70	r_s = − 0.51	0.11
Hippocampal Aβ42 (%Area)	r_s = − 0.72	r_s = − 0.51	0.073
Cortical dense-core plaques (%Area)	r_s = − 0.67	r_s = − 0.52	0.22
Hippocampal dense-core plaques (%Area)	r_s = − 0.67	r_s = − 0.49	0.15
TBS-soluble Aβ42 (pg/mg cortical tissue)	r_s = − 0.74	r_s = − 0.46	0.018
FA-soluble Aβ42 (pg/mg cortical tissue)	r_s = − 0.67	r_s = − 0.52	0.22

Correlation analyses were performed using Spearman’s rank-ordered correlation coefficient. Differences between correlation coefficients were estimated using Meng’s Z-test
Abbreviations: Aβ amyloid beta, CSF cerebrospinal fluid, FA formic acid, TBS tris-buffered saline

ISSN: 1758-9193