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Table 2 Risk of dementia between the RLS and control groups

From: Restless leg syndrome and risk of all-cause dementia: a nationwide retrospective cohort study

 

Cases, n (%)

Stratified Cox regression model

Crude HR (95% CI)

p-value

aHRa (95% CI)

p-value

All-cause dementia

 RLS group

260 (10.4)

1.74 (1.51–2.02)

 < 0.001

1.46 (1.24–1.72)

 < 0.001

 Control group

614 (6.2)

1 (reference)

 

1 (reference)

 

AD

 RLS group

139 (5.6)

1.68 (1.38–2.05)

 < 0.001

1.38 (1.1–1.72)

0.004

 Control group

336 (3.4)

1 (reference)

 

1 (reference)

 

VaD

 RLS group

64 (2.6)

1.98 (1.46–2.69)

 < 0.001

1.81 (1.30–2.53)

 < 0.001

 Control group

130 (1.3)

1 (reference)

 

1 (reference)

 
  1. Abbreviations: AD, Alzheimer’s disease; aHR, adjusted hazard ratio; CCI, Charlson Comorbidity Index; CI, confidence interval; HR, hazard ratio; RLS, restless leg syndrome; VaD, Vascular dementia
  2. aAdjusted for income, region, CCI score, history of sleep disorder, schizophrenia or other psychotic disorders, mood disorder, anxiety disorder, Parkinson’s disease, and iron deficiency anemia