Exploring the ATN classification system using brain morphology

Table 3 Comparing progression sequences towards AD pathology including non-AD continuum groups in selected ROIs

Region	Best sequence	T	P	ACH on rank nr. (of 6)	ACH VX%
AMG	ACH	−12.93	8.22e−33	1	89.62
Hippocampus	ANT	−18.07	5.74e−55	2	58.18
Entorhinal cortex	ACH	−7.25	9.78e−13	1	89.05
Precuneus	ACH	−3.93	4.86e−05	1	30.92
Braak I/II	ACH	−16.20	1.07e−46	1	57.95
Braak III/IV	ANT	−7.67	5.64e−14	2	46.02
Braak V/VI	ANT	−4.21	1.53e−05	2	28.60

ROI-based comparison of evidence for a monotonic volume decline over 6 possible sequences across ATN groups from A−T−N− towards A+T+N+ (ACH, ANT, TAN, TNA, NAT, NTA). Braak stage volumes are aggregated Freesurfer volumes of regions that mirror Braak stages. ACH VX% percentage of voxels with highest evidence for ACH sequence inside the ROI mask

ISSN: 1758-9193