Fig. 5

Face validity of ACH using VBM. Voxel-based evidence for monotonic volume decline over 24 sequences gained by permutation of the ACH sequence (ACH, A−T−N−➔A+T−N−➔A+T+N−➔A+T+N+); AP 1: A+T−N−➔A+T+N−➔A−T−N−➔A+T+N+; AP 2: A+T−N−➔A−T−N−➔A+T+N−➔A+T+N+; A voxels where sequence shows highest evidence; B percentage of gray matter voxels where sequence has highest evidence