Table 2 Neuropsychological assessment in representative participants
From: Clinical features and biomarkers of semantic variant primary progressive aphasia with MAPT mutation
| Â | svPPA N=2 | Presymptomatic carriers N=7 | Noncarriers N=9 | P-value | |||||
|---|---|---|---|---|---|---|---|---|---|
Representative subjects | III-12 | IV-22 | IV-2 | IV-30 | Mean (SD) | IV-32 | IV-33 | Mean (SD) | Â |
Age (years) | 64 | 50 | 57 | 41 | 42 (7) | 35 | 36 | 41 (12) | 0.865 |
Years of education | 9 | 12 | 5 | 12 | 8 (2) | 9 | 12 | 10 (7) | 0.421 |
MMSE | 17 | 17 | 23 | 30 | 27 (3) | 29 | 30 | 24 (7) | 0.368 |
MoCA | 10 | 11 | 24 | 26 | 25 (1) | 27 | 27 | 21 (9) | 0.248 |
TMT part A (seconds) | UC | 66 | 84 | 30 | 42 (18) | 34 | 29 | 42 (12) | 0.576 |
TMT part B (seconds) | UC | 180 | 234 | 60 | 96 (60) | 36 | 60 | 72 (18) | 0.357 |
Stroop words | 40 | 66 | 60 | 72 | 73 (12) | 74 | 95 | 85 (18) | 0.197 |
Stroop colours | 26 | 25 | 50 | 63 | 61 (15) | 57 | 60 | 68 (25) | 0.51 |
Stroop interference | 14 | 2 | 11 | 32 | 30 (11) | 23 | 23 | 33 (15) | 0.724 |
SDMT | 8 | 32 | 10 | 50 | 43 (17) | 44 | 43 | 59 (13) | 0.082 |
AVLT total learning | 16 | 45 | 32 | 43 | 42 (14) | 52 | 40 | 54 (11) | 0.091 |
AVLT delayed recall | 0 | 9 | 10 | 11 | 10 (2) | 11 | 11 | 9 (5) | 0.552 |
AVLT recognition | 2 | 9 | 5 | 14 | 14 (0.7) | 11 | 12 | 13 (3) | 0.321 |
BVMT-R total learning | 7 | 6 | 16 | 22 | 21 (8) | 30 | 30 | 21 (11) | 0.942 |
BVMT-R delayed recall | 4 | 2 | 6 | 7 | 9 (3) | 12 | 11 | 9 (4) | 0.906 |
BVMT-R recognition | 5 | 1 | 6 | 5 | 6 (3) | 6 | 6 | 5 (2) | 0.122 |
COWAT | 3 | 2 | 9 | 17 | 6 (3) | 21 | 20 | 6 (3) | 0.611 |
AFT | 7 | 1 | 10 | 14 | 15 (5) | 21 | 20 | 18 (6) | 0.316 |
BNT | 12 | 6 | 30 | 30 | 29 (3) | 29 | 29 | 28 (4) | 0.639 |
Digit span forward | 10 | 16 | 10 | 13 | 14 (2) | 14 | 12 | 12 (4) | 0.201 |
Digit span backward | 3 | 5 | 5 | 7 | 8 (3) | 6 | 5 | 7 (4) | 0.404 |
ADL | 20 | 20 | 20 | 20 | 20 (0) | 20 | 20 | 20 (0) | ND |
NPI | 13 | 0 | 0 | 1 | 0.9 (0.9) | 0 | 0 | 0.8 (1.3) | 0.893 |