Fig. 2
From: Clinical features and biomarkers of semantic variant primary progressive aphasia with MAPT mutation
Neuroimaging presentations of the svPPA patient and two presymptomatic carriers. A IV-22 (svPPA patient): bilateral frontal atrophy and bilateral but left-dominant atrophy of the anterior temporal lobes on brain MRI; hypometabolism in the bilateral temporal cortex, frontal cortex, insula and caudate nucleus on FDG PET; and diffuse tracer binding in the temporal and frontal lobes of the cerebrum on tau-PET. B IV-2 (presymptomatic carrier with abnormal cognitive assessment): no visually obvious atrophy of the bilateral frontal and temporal lobes on brain MRI; focal hypometabolism of the bilateral frontal lobes on FDG PET; diffuse tracer binding in the temporal and frontal lobes of the cerebrum on tau-PET. C IV-30 (presymptomatic carrier with normal cognitive assessment): no obvious atrophy, hypometabolism or tau accumulation on brain MRI and PET scans. There is “off-target” binding in brain areas without tau deposition, such as the brain stem and the basal ganglia