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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Decreased ratios of matrix metalloproteinases to tissue-type inhibitors in cerebrospinal fluid in sporadic and hereditary cerebral amyloid angiopathy

Fig. 4

Univariate analysis of MMP/TIMP ratios in CSF of (pre-)symptomatic D-CAA patients and controls. In the pre-symptomatic D-CAA group, no significant differences were found in MMP/TIMP ratios between D-CAA patients and their age-matched controls. In the symptomatic D-CAA group, significant decreases of MMP-14/TIMP-2 ratios (Mann–Whitney U, p = 0.04) and MMP-14/TIMP-3 ratios (Mann–Whitney U, p = 0.04) were found, relative to their respective age-matched controls. Crossed-out symbols signify statistically significant outliers (Grubbs test). Significance levels and accompanying p-values are of uncorrected comparisons. *p < 0.05, ns p > 0.05

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Alzheimer's Research & Therapy

ISSN: 1758-9193