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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: How does apolipoprotein E genotype influence the relationship between physical activity and Alzheimer’s disease risk? A novel integrative model

Fig. 2

Hypothesised associations between apolipoprotein E gene allele, physical activity and neurotrophic factors. Solid lines indicate empirically supported pathways, and dashed lines indicate hypothesised pathways with preliminary evidence. Green lines indicate a positive effect, and red lines indicate a negative effect. E4 > E2 indicates a greater effect for E4 carriers compared to E2 carriers, and E4 > E3 indicates a greater effect for E4 carriers compared to E3 carriers. Abbreviations: Aβ amyloid-beta, APOE apolipoprotein E, BDNF brain-derived neurotrophic factor, IGF insulin-like growth factor, p-tau phosphorylated tau, VEGF vascular endothelial growth factor. Created by KS with BioRender.com

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Alzheimer's Research & Therapy

ISSN: 1758-9193