Efficacy and safety of the novel GlyT1 inhibitor BI 425809 in Alzheimer’s dementia: a randomized controlled trial

Table 5 Change from baseline in ADAS-Cog₁₁ total score: MCPmod test for non-flat dose-response curve

Multiple contrast test^a	Linear	Logistic	Emax	sigEmax	Linear in log	betaMod
t-Stat	0.0501	− 0.1024	− 0.4898	− 0.5233	− 0.5504	− 1.2587
Adjusted p-value	0.7646	0.8199	0.9225	0.9287	0.9335	0.9931

Data analyzed were the mean change from baseline to week 12 in ADAS-Cog11 total score
ADAS-Cog₁₁ Alzheimer’s Disease Assessment Scale-Cognitive Subscale 11, MCPMod multiple comparison procedure and modeling
^aCritical value for t-Stat: 2.084, alpha = 0.05, one-sided

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