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Table 1 mRNA expression levels of chemokine genes in brain tissues from 269 AD patients and 271 controls

From: Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer’s disease

Gene

Entorhinal cortex

Hippocampus

Temporal cortex

Frontal cortex

logFC

P

logFC

P

logFC

P

logFC

P

C–C motif chemokine ligand

 CCL1

 − 0.13

0.413

0.09

0.498

 − 0.28

0.229

0.02

0.82

 CCL2

0.68

0.021*

0.63

0.007*

0.52

0.094

0.19

0.351

 CCL5

0.17

0.17

0.46

0.001*

0.64

0.001*

0.02

0.841

 CCL8

0.43

0.017*

0.32

0.081

0.12

0.619

 − 0.19

0.066

 CCL11

0.23

0.128

 − 0.16

0.213

0.19

0.409

0.01

0.901

 CCL16

0.18

0.194

0.29

0.056

 − 0.07

0.785

 − 0.13

0.211

C–C motif chemokine receptor

 CCR1

0.28

0.127

0.32

0.006*

0.4

0.008*

0.26

0.008*

 CCR3

0.11

0.398

0.22

0.143

0.01

0.973

 − 0.06

0.61

 CCR5

NA

NA

0.38

0.006*

NA

NA

 − 0.02

0.864

 CCR6

0.12

0.411

 − 0.02

0.892

 − 0.18

0.464

 − 0.08

0.46

 CCR7

0.32

0.034*

0.15

0.279

 − 0.09

0.748

0.07

0.398

 CCR9

0.27

0.036*

 − 0.08

0.61

 − 0.04

0.838

 − 0.04

0.692

 CCRL2

0.18

0.206

NA

NA

0.28

0.207

 − 0.01

0.923

C-X-C motif chemokine ligand

 CXCL1

0.21

0.263

0.26

0.18

0.79

8.89 × 10−5*

0.39

0.012*

 CXCL2

0.23

0.192

0.2

0.257

0.17

0.405

0.09

0.483

 CXCL6

0.41

0.005*

0.04

0.805

 − 0.07

0.807

 − 0.06

0.635

 CXCL8

0.28

0.274

0.53

0.004*

 − 0.06

0.729

0.03

0.816

 CXCL9

0.31

0.016*

 − 0.16

0.281

0.43

0.07

0.2

0.133

 CXCL10

0.45

0.097

0.35

0.168

0.71

0.007*

0.41

0.026*

 CXCL11

0.24

0.165

0.12

0.406

 − 0.1

0.691

0.17

0.275

 CXCL13

0.16

0.289

 − 0.06

0.655

 − 0.09

0.754

 − 0.03

0.752

 CXCL16

0.38

0.011*

0.29

0.012*

0.64

2.16 × 10−4*

NA

NA

C-X-C motif chemokine receptor

 CXCR2

NA

NA

0.26

0.088

 − 0.05

0.849

 − 0.03

0.847

 CXCR4

0.8

3.3 × 10−4*

0.56

0.001*

0.55

0.003*

0.5

3.79 × 10−5*

 CXCR5

0.03

0.776

0.11

0.32

0.08

0.712

 − 0.12

0.22

 CXCR6

0.14

0.245

0.16

0.091

0.16

0.278

0.2

0.011*

C-X3-C motif chemokine receptor

 CX3CR1

0.06

0.759

 − 0.09

0.589

 − 0.12

0.535

0.08

0.569

X-C motif chemokine receptor

 XCR1

0.1

0.392

0

0.977

0.09

0.637

0.01

0.884

  1. The mRNA expression data were retrieved from the AlzData database (www.alzdata.org) [41], with no data available for CCL3, CCL14, and CCL15
  2. A p value < 0.05 was marked with “*,” and a p value < 0.0018 after Bonferroni correction for the number of tested genes (0.05/28) was marked in bold
  3. LogFC, log2 fold change of mRNA expressional mean value in AD patients relative to that in controls
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Alzheimer's Research & Therapy

ISSN: 1758-9193