Fig. 3

Correlation of upregulated mRNA levels of Ccl5 (A), Cxcl1 (B), and Cxcl16 (C) with Aβ and tau pathology in AD mouse models. Original data were retrieved from Mouseac (www.mouseac.org) [43]. The age-related mRNA expression level was measured in 114 brain tissues from wild-type mice (WILD), 44 brain tissues from homozygous APP/PSEN1 double mutant mice (HO_TASTPM), and 45 brain tissues from mutant human MAPT mice (TAU) at different ages. The scores of Aβ pathology and tau pathology were based on 44 brain tissues of HO_TASTPM mice and 45 brain tissues of TAU mice, respectively. Error bars represent the population standard deviation. **, P < 0.01; ****, P < 0.0001; two-tailed Student’s t-test for comparison of mRNA expression between AD transgenic mice and WILD mice at month 18. The correlation between mRNA expression levels and pathology was measured using the Pearson correlation analysis. The solid and dashed lines represent the slope and the 95% confidence intervals in linear regression