Fig. 2

Upregulated mRNA expression levels of chemokine genes in brain tissues of AD patients. A–D The mRNA expression data were retrieved from the AlzData (www.alzdata.org) [41]. Data of CXCL16 was not available in the frontal cortex tissues. Data from min to max were presented by dots. The lower and upper hinges of the boxes represent the first and third quantiles, the whiskers extend from min to max, and the line represents the median. EC, entorhinal cortex; HP, hippocampus; TC, temporal cortex; FC, frontal cortex; Ns, not significant. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; two-tailed Student’s t-test