Table 3 Effects of the co-occurrence of APOE4 and FH of AD (APOE4+FH) on the relationship between T1w/T2w ratio values and rs-FC
From: Effects of non-modifiable risk factors of Alzheimer’s disease on intracortical myelin content
FC seed Peak location of significant result | Extent of change (mm2) | MNI coordinates | F | P | f2 |
|---|---|---|---|---|---|
L precentral (lower T1w/T2w ratio in APOE4+FH) | |||||
R precuneus | 138 | 14 − 44 54 | 15.5 | 10−2 | 0.23M |
R precentral (lower T1w/T2w ratio in APOE4+FH) | |||||
R paracentral | 162 | 9 − 21 48 | 25.4 | 10−3 | 0.37L |
L entorhinal (higher T1w/T2w ratio in APOE4+FH) | |||||
L rostral middle frontal | 435 | − 23 53 1 | 17.2 | 10−3 | 0.25M |
R medial orbitofrontal (higher T1w/T2w ratio in APOE4+FH) | |||||
L superior frontal | 172 | − 7 57 9 | 12.6 | 10−2 | 0.19M |
L anterior cingulate | 108 | − 6 32 − 10 | 11.3 | 10−2 | 0.17M |