Table 2 Group differences in T1w/T2w ratio maps
From: Effects of non-modifiable risk factors of Alzheimer’s disease on intracortical myelin content
Statistical contrast Peak location | Extent of change (mm2) | MNI coordinates | F | P | f2 |
|---|---|---|---|---|---|
Control > APOE4 | |||||
L lingual gyrus | 185 | − 23 − 66 4 | 17.3 | 10−4 | 0.18M |
Control > FH | |||||
R paracentral | 271 | 3 − 38 68 | 21.9 | 10−5 | 0.21M |
R posterior cingulate | 61 | 4 − 4 31 | 17.2 | 10−4 | 0.17M |
FH > control | |||||
L inferior temporal | 96 | − 54 − 28 − 28 | 16.9 | 10−7 | 0.16M |
L entorhinal | 195 | − 35 − 19 − 29 | 19.3 | 10−6 | 0.19M |
L fusiform gyrus | 243 | − 30 − 5 − 39 | 17.3 | 10−4 | 0.17M |
L rostral anterior cingulate | 72 | − 5 29 − 5 | 14.1 | 10−3 | 0.14S |
L caudal anterior cingulate | 192 | − 11 21 29 | 13.8 | 10−2 | 0.13S |
R middle temporal | 2012 | 48 8 − 37 | 17.5 | 10−7 | 0.17M |
R fusiform gyrus | 95 | 38 − 21 − 29 | 16.6 | 10−6 | 0.16M |
R rostral anterior cingulate | 103 | 3 22 − 8 | 15.5 | 10−5 | 0.15M |
R medial orbitofrontal | 158 | 6 48 − 24 | 19.3 | 10−4 | 0.19M |
R postcentral | 100 | 59 − 11 14 | 13.6 | 10−2 | 0.13S |
Control > APOE4+FH | |||||
L isthmus cingulate | 213 | − 6 − 34 26 | 27.7 | 10−6 | 0.41L |
L precentral | 852 | − 12 − 25 74 | 20.5 | 10−6 | 0.30M |
L pericalcarine | 476 | − 21 − 71 7 | 15.8 | 10−5 | 0.23M |
L paracentral | 261 | − 6 − 24 56 | 27.3 | 10−3 | 0.40L |
R pericalcarine | 886 | 11 − 80 11 | 20.9 | 10−6 | 0.31M |
R paracentral | 506 | 4 − 28 53 | 27.3 | 10−6 | 0.40L |
R precentral | 1162 | 8 − 33 70 | 25.3 | 10−6 | 0.37L |
R precentral | 683 | 48 − 7 28 | 26.8 | 10−5 | 0.39L |
R transverse temporal | 433 | 59 − 9 4 | 23.5 | 10−4 | 0.35L |
APOE4+FH > control | |||||
L medial orbitofrontal | 1179 | − 5 23 − 13 | 21.2 | 10−6 | 0.31M |
L entorhinal | 1481 | − 24 3 − 39 | 17.7 | 10−6 | 0.26M |
L medial orbitofrontal | 119 | − 7 29 − 23 | 24.7 | 10−6 | 0.36L |
L insula | 674 | − 29 21 10 | 16.9 | 10−5 | 0.25M |
L lateral orbitofrontal | 136 | − 27 11 − 20 | 16.3 | 10−4 | 0.24M |
R lateral orbitofrontal | 3907 | 33 23 − 21 | 31.6 | 10−6 | 0.46L |
R caudal anterior cingulate | 807 | 5 28 18 | 25.7 | 10−6 | 0.38L |
R medial orbitofrontal | 317 | 5 26 − 13 | 20.6 | 10−6 | 0.30M |
APOE4 > APOE4+FH | |||||
L pericalcarine | 160 | − 7 − 90 4 | 16.1 | 10−3 | 0.19M |
L insula | 268 | − 31 − 27 17 | 14.1 | 10−3 | 0.17M |
L precentral | 255 | − 42 − 13 34 | 19.7 | 10−2 | 0.24M |
R precentral | 258 | 59 − 2 22 | 17.8 | 10−3 | 0.21M |
R paracentral | 220 | 4 − 28 52 | 21.2 | 10−3 | 0.26M |
APOE4+FH > APOE4 | |||||
L medial orbitofrontal | 264 | − 7 35 − 23 | 27.7 | 10−6 | 0.33M |
R medial orbitofrontal | 96 | 3 33 − 22 | 20.2 | 10−5 | 0.20M |
Control > APOE4 or FH | |||||
L lingual gyrus | 374 | − 14 − 77 8 | 16.2 | 10−5 | 0.09S |
L superior parietal | 653 | − 28 − 55 51 | 18 | 10−4 | 0.1S |
R paracentral | 249 | 3 − 38 68 | 20.1 | 10−6 | 0.11S |
R superior parietal | 507 | 26 − 79 41 | 20.3 | 10−3 | 0.12S |
R precentral | 371 | 26 − 26 52 | 15.6 | 10−2 | 0.08S |
APOE4 or FH > Control | |||||
L superior temporal | 743 | − 51 − 14 − 8 | 17.4 | 10−5 | 0.09S |
L pars orbitalis | 118 | − 41 36 − 14 | 13.7 | 10−4 | 0.07S |
L fusiform gyrus | 122 | − 32 − 7 − 41 | 12.6 | 10−3 | 0.07S |
R superior temporal | 2641 | 48 5 − 25 | 15.1 | 10−7 | 0.08S |
R lateral orbitofrontal | 166 | 26 22 − 23 | 14.3 | 10−5 | 0.08S |
R supramarginal | 406 | 55 − 29 34 | 19 | 10−4 | 0.1S |