Fig. 4
From: Effects of non-modifiable risk factors of Alzheimer’s disease on intracortical myelin content
Effects of the co-occurrence of APOE4 and FH of AD (APOE4+FH) on the relationship between rT1w/T2w ratio levels and rs-FC patterns. Upper panel: results obtained with FC seeds that showed lower rT1w/T2w ratios in the APOE4+FH group compared with controls. Analyses showed a positive relationship in the APOE4+FH group and a negative relationship in controls. Bottom panel: results obtained with FC seeds that showed higher rT1w/T2w ratios in the APOE4+FH group compared with controls. The relationship was negative in both groups but it was more negative in the APOE4+FH group than in controls. Analyses were adjusted by age and sex and corrected for multiple comparisons. Warm and cold scale bars indicate the range of significant t-values for the direction of the statistical contrast. Left (L) and right (R). mOFC, medial orbitofrontal cortex