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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer’s disease

Fig. 2

A summary of the SILK experiment. This experiment was conducted in one subject (501–110) on a daily 200-mg EFV dose. A Ion abundance at m/z corresponding to the incorporation of one (504), two (505), and three (506) 2H into plasma 24-hydroxycholesterol (24HC). The peak at m/z 503 represents the sterol molecular ion. The data for week 0 show the background natural abundance of the 24HC mass isotopomers. B Plasma 24HC and body water (inset) enrichment with 2H. The dashed line indicates the areas under the curve (AUC), which were used for the estimation of the EFV effect on CYP46A1 activity. W, week of the clinic visit. EFV treatment stopped at W 20

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Alzheimer's Research & Therapy

ISSN: 1758-9193