Table 2 Interaction between α-synuclein and tau
From: Alpha-synuclein: a pathological factor with Aβ and tau and biomarker in Alzheimer’s disease
Types of ligands | Types of α-syn | Consequences |
|---|---|---|
Tau | α-syn | Tau phosphorylation↑ [50, 59,60,61,62] Tau aggregation↑ [52] |
α-syn fibril | Tau-mediated microtubule assembly↓ [54] Tau phosphorylation↑ [58] | |
A30P α-syn | α-syn and tau interaction↓ [55] or ↑ [56] or no effect [50] Tau-mediated microtubule assembly↓[56] | |
E46K α-syn | α-syn and tau interaction↑ [56] or no effect [55] Tau-mediated microtubule assembly↓ [56] | |
A53T α-syn | α-syn and tau interaction↑ [56] or no effect [50, 55] Tau-mediated microtubule assembly↓ [56] | |
P301L Tau | α-syn | α-syn and tau interaction↓ [57] α-syn aggregation↑ [57] Tau aggregation↑ [57] |
α-syn fibril | Tau aggregation↑ [58] |