Fig. 1

Schematic display of patient selection and assignment to analyzed groups. RATL, right-predominant, LATL, left-predominant, BILATL, symmetric neurodegeneration of the ATL. *The target hypometabolism, a metabolic pattern for svPPA or SD, was defined as predominant hypometabolism of the left, right, or both ATL. This hypometabolism may extend to frontal and (inferior) parietal cortices, but with a clear-cut gradient from the temporal pole to other regions and without clearly suggesting other neurodegenerative syndromes or diseases (e.g., Alzheimer’s disease, behavioral variant FTD, dementia with Lewy bodies, or atypical parkinsonian syndromes)