Fig. 5
Association of plasma Aβ42/Aβ40 at baseline with longitudinal measures of clinical diagnosis, brain amyloid deposition and brain atrophy at 2-year follow-up. A Distribution of plasma Aβ42/Aβ40 levels at baseline between subjective cognitive decline (SCD) and mild cognitive impairment (MCI) individuals at 2-year follow-up. Plasma Aβ42/Aβ40 levels were compared between SCD and MCI groups using Mann Whitney test. ** P < .01. Horizontal line depicts median and whiskers depict interquartile range. B Kaplan-Meier curves showing fraction of individuals remaining SCD. P value of log-rank test is depicted in the lower right. C Distribution of plasma Aβ42/Aβ40 levels at baseline between Aβ-PET(−), Aβ-PET(+) and Aβ-PET(+) converter subjects at 2-year follow-up. Aβ-PET(+) converter subjects were defined as individuals who converted from Aβ-PET(−) at baseline to Aβ-PET(+) at 2-year follow-up. Plasma Aβ42/Aβ40 levels were compared among groups using Kruskal-Wallis test followed by the Dunn’s pairwise test with adjustment for multiple comparisons. * P < .05; *** P < .001. Horizontal line depicts median and whiskers depict interquartile range. D Kaplan-Meier curves showing fraction of individuals remaining Aβ-PET(−). P value of log-rank test is depicted in the lower right. E, G Correlations between plasma Aβ42/Aβ40 at baseline and amyloid accumulation (E) and brain atrophy (G) at 2-year follow-up, as determined by Aβ-PET CL and ventricular volume increments. Solid blue line represents the regression line; dashed lines represent 95% confidence interval. F, H Distribution of Aβ-PET CL (F) and ventricular volume (H) increments among the quartiles of plasma Aβ42/Aβ40 at baseline. Aβ-PET CL and ventricular volume increments were compared using Kruskal-Wallis test followed by the Dunn’s pairwise test with adjustment for multiple comparisons. ** P < .01; *** P < .001. Horizontal line depicts median and whiskers depict interquartile range. Abbreviations: CL, centiloid; Δ, increment; MCI, mild cognitive impairment; ns, non-significant; Q, quartile; SCD, subjective cognitive decline