CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals

Table 2 The relationship between tau368/t-tau and tau PET symptomatic AD is not affected by amyloid

Independent variables		R²	Adj. R²	AICc
Amyloid composite		7%	3%	− 183.2
Transentorhinal tau (I–II)	Tau	6%	1%	− 182.8
Transentorhinal tau (I–II)	Amyloid + Tau	10%	2%	− 181.1
Limbic tau (III–IV)	Tau	32%	29%	− 190.6^a
Limbic tau (III–IV)	Amyloid + Tau	33%	27%	− 188.2
Isocortical tau (V–VI)	Tau	41%	38%	− 193.9^a
Isocortical tau (V–VI)	Amyloid + Tau	42%	36%	− 191.3

Associations between tau PET SUVr and tau368/t-tau in the hierarchical Braak stages demonstrate that the associations strengthen in the later Braak stages. R² and adjusted R², measures of how the outcome variable is explained by the models, are shown. Akaike information criteria with correction for small sample sizes (AICc) was calculated to determine the best fitting model, accounting for the complexity of the model. An AIC < 2 compared to another model indicates less information loss, and thus a better model^a
*P < 0.01

ISSN: 1758-9193