Skip to main content

Table 2 Association of habitual glucosamine use and risk of dementia

From: The role of type 2 diabetes in the association between habitual glucosamine use and dementia: a prospective cohort study

 

Dementia

Alzheimer’s disease

Vascular dementia

Glucosamine non-users

Glucosamine users

Glucosamine non-users

Glucosamine users

Glucosamine non-users

Glucosamine users

No. of events

5418

1413

1361

429

754

169

Incidence ratea

0.20 (0.19–0.20)

0.21 (0.19–0.22)

0.05 (0.04–0.05)

0.06 (0.05–0.07)

0.03 (0.02–0.03)

0.03 (0.02–0.03)

Hazard ratios (95% CI)

 Model 1b

1 (Reference)

0.84 (0.79–0.89)

1 (Reference)

0.96 (0.86–1.07)

1 (Reference)

0.71 (0.60–0.84)

 Model 2c

1 (Reference)

0.90 (0.84–0.95)

1 (Reference)

0.98 (0.88–1.10)

1 (Reference)

0.81 (0.69–0.97)

 Model 3d

1 (Reference)

0.87 (0.82–0.93)

1 (Reference)

0.97 (0.86–1.08)

1 (Reference)

0.82 (0.69–0.98)

  1. aPer 1000 person-years (95% CI)
  2. bModel 1: Cox proportional hazards regression adjusted for age (timescale) and sex
  3. cModel 2: Cox proportional hazards regression adjusted for age (timescale), sex, ethnicity, BMI, education attainment, Townsend deprivation index, smoking status, alcohol consumption, family history of dementia, hypertension, arthritis, total cholesterol, healthy diet, and APOE ε4 carrier.
  4. dModel 3: Cox proportional hazards regression adjusted for age (timescale), sex, ethnicity, BMI, education attainment, Townsend deprivation index, smoking status, alcohol consumption, family history of dementia, hypertension, arthritis, total cholesterol, healthy diet, APOE ε4 carrier, mineral and vitamin supplements use, and aspirin use
Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193