Table 3 Symptoms causing patients most distress and symptoms that patients would most likely prioritize for treatment

Symptom domain

n (%)

Symptom domain

n (%)

Parkinsonism

46 (17.5)

Parkinsonism

49 (18.6)

Cognitive impairment

40 (15.2)

Cognitive impairment

47 (17.9)

Autonomic dysfunction

35 (13.3)

Autonomic dysfunction

21 (8.0)

Psychiatric symptoms

19 (7.2)

Sleep-related disorders

15 (5.7)

Sleep-related disorders

15 (5.7)

Psychiatric symptoms

12 (4.6)

Eating behavior-related problems

5 (1.9)

Eating behavior-related problems

4 (1.5)

Sensory disorders

0 (0.0)

Sensory disorders

0 (0.0)

Symptom

n (%)

Symptom

n (%)

Memory impairment

23 (8.7)

Memory impairment

30 (11.4)

Constipation

20 (7.6)

Bradykinesia/akinesia

20 (7.6)

Bradykinesia/akinesia

17 (6.5)

Abnormal posture

8 (3.0)

Visual hallucinations

8 (3.0)

Constipation

7 (2.7)

Nighttime sleep disorder

7 (2.7)

Nighttime dysuria

7 (2.7)

Abnormal posture

6 (2.3)

Nighttime sleep disorder

7 (2.7)

Gait disturbance

6 (2.3)

Visual hallucinations

7 (2.7)

Nighttime dysuria

6 (2.3)

Attention dysfunction

6 (2.3)

Rapid eye movement sleep behavior disorder

6 (2.3)

Gait disturbance

6 (2.3)

Daytime dysuria

5 (1.9)

Rapid eye movement sleep behavior disorder

6 (2.3)

Anxiety

4 (1.5)

Action tremor

5 (1.9)

Attention dysfunction

4 (1.5)

Disorientation

4 (1.5)

Other cognitive impairment

4 (1.5)

Fall

3 (1.1)

Postural instability

4 (1.5)

Other cognitive impairment

3 (1.1)

Action tremor

3 (1.1)

Daytime dysuria

2 (0.8)

Disorientation

3 (1.1)

Daytime somnolence

2 (0.8)

Disturbance of sweating

3 (1.1)

Disturbance of sweating

2 (0.8)

Executive dysfunction

3 (1.1)

Fluctuating cognition

2 (0.8)

Freezing of gait

3 (1.1)

Freezing of gait

2 (0.8)

Hallucinations other than visual hallucinations

3 (1.1)

Hallucinations other than visual hallucinations

2 (0.8)

Salivation

3 (1.1)

Orthostatic hypotension

2 (0.8)

Depression

2 (0.8)

Postural instability

2 (0.8)

Fall

2 (0.8)

Weight loss

2 (0.8)

Fluctuating cognition

2 (0.8)

Agitation/aggression

1 (0.4)

Weight gain

2 (0.8)

Anxiety

1 (0.4)

Weight loss

2 (0.8)

Delusions

1 (0.4)

Day–night reversal

1 (0.4)

Dizziness

1 (0.4)

Daytime somnolence

1 (0.4)

Dysphagia

1 (0.4)

Delusions

1 (0.4)

Executive dysfunction

1 (0.4)

Loss of appetite

1 (0.4)

Loss of appetite

1 (0.4)

Orthostatic hypotension

1 (0.4)

Rigidity

1 (0.4)

Other psychiatric symptoms

1 (0.4)

Salivation

1 (0.4)

Rest tremor

1 (0.4)

Visuospatial dysfunction

1 (0.4)

Rigidity

1 (0.4)

Weight gain

1 (0.4)

Visuospatial dysfunction

1 (0.4)

Aberrant motor behavior

0 (0.0)

Aberrant motor behavior

0 (0.0)

Apathy

0 (0.0)

Agitation/aggression

0 (0.0)

Day–night reversal

0 (0.0)

Apathy

0 (0.0)

Delirium

0 (0.0)

Delirium

0 (0.0)

Depression

0 (0.0)

Disinhibition

0 (0.0)

Disinhibition

0 (0.0)

Dizziness

0 (0.0)

Dysosmia

0 (0.0)

Dysosmia

0 (0.0)

Eating non-edible things

0 (0.0)

Dysphagia

0 (0.0)

Food refusal

0 (0.0)

Eating non-edible things

0 (0.0)

Increase in appetite

0 (0.0)

Food refusal

0 (0.0)

Negativism

0 (0.0)

Increase in appetite

0 (0.0)

Other psychiatric symptoms

0 (0.0)

Negativism

0 (0.0)

Periodic limb movement disorder

0 (0.0)

Periodic limb movement disorder

0 (0.0)

Rest tremor

0 (0.0)

Restless legs syndrome

0 (0.0)

Restless legs syndrome

0 (0.0)

Sudden sleep

0 (0.0)

Sudden sleep

0 (0.0)

Syncope

0 (0.0)

Syncope

0 (0.0)

Unbalanced diet

0 (0.0)

Unbalanced diet

0 (0.0)

Invalid answer

103 (39.2)

Invalid answer

115 (43.7)

 Multiple answers

60 (22.8)

 Multiple answers

59 (22.4)

 Do not know

31 (11.8)

 Do not know

41 (15.6)

 Unanswered

12 (4.6)

 Unanswered

15 (5.7)