Fig. 5

YIAD002 moderately dissociates tau aggregation by interacting with R2 and R3. A Dissociative effects of YIAD001 and YIAD002 against K18 aggregation were evaluated using ThT fluorescence. Dissociative interactions by YIAD002 with tau fragments R1 (B), R2 (C), R3 (D), and R4 (E) were evaluated by ThT fluorescence. Docking models of YIAD002 interaction with tau R2 (F) and R3 (G). Aggregation times are indicated as “+” for 3 days, and “++” for 6 days. All statistical comparisons were made with the pre-aggregation control (+). One-way analysis of variance followed by Bonferroni’s post hoc comparisons tests were performed in all statistical analyses (*P < 0.05, ***P < 0.001, ****P < 0.0001). Data are presented as mean ± SEM. Abbreviations: Conc. = concentration, Agg. = aggregation, Cpd. = compound, Fluor. = fluorescent