Fig. 5

Aβ plaque reduction with gantenerumab in basal ganglia before and up to 36 months after treatment, and reduction of amyloid burden toward zero centiloids after 36 months of open-label therapy. A Axial florbetapir brain PET images from 3 patients displaying different rates of reduction of Aβ plaques from OLE baseline to OLE week 52 and OLE week 104. Axial slices are at the level of the basal ganglia. PET images were obtained 50 min post-injection, standardized uptake value data with the cerebellar cortex as the reference region. ^a18F-Florbetapir amyloid PET. ^bLS mean (SE) analyzed using a mixed model for repeated measures; 1200 mg subcutaneous gantenerumab was administered every 4 weeks during the OLE studies. B Marked and consistent reduction of amyloid load in patients receiving high-dose gantenerumab. Marked reduction of amyloid-β plaques in patients receiving high-dose gantenerumab, and consistent reduction of amyloid-β plaques in all patient groups. B adapted from Klein G, et al. J Prev Alzheimers Dis. 2021;8(1):3-6, licensed under CC BY 4.0