Table 2 Summary of sex × plasma MMP-9 interaction effects on AD biomarkers in the whole cohort and in diagnosis-stratified analyses
From: Sex differences in Alzheimer’s disease: plasma MMP-9 and markers of disease severity
Interaction between sex and plasma MMP-9 on CSF t-tau | ||||||
Whole cohort | MCI | AD | ||||
β (95% CI) | p value | β (95% CI) | p value | β (95% CI) | p value | |
Sex × free MMP-9 | 98.61 (33.61 to 163.62) | 0.003 | 64.03 (−19.49 to 147.55) | 0.1 | 163.81 (49.67 to 277.95) | 0.005 |
Sex × total MMP-9 | 128.68 (55.37 to 201.99) | <0.001 | 119.04 (32.09 to 205.99) | 0.008 | 111.33 (−46.47 to 269.13) | 0.2 |
Interaction between sex and plasma MMP-9 on CSF p-tau181 | ||||||
Whole cohort | MCI | AD | ||||
β (95% CI) | p value | β (95% CI) | p value | β (95% CI) | p value | |
Sex × free MMP-9 | 21.70 (0.65 to 42.76) | 0.043 | 16.25 (−10.46 to 42.96) | 0.2 | 34.27 (−1.91 to 70.46) | 0.06 |
Sex × total MMP-9 | 21.49 (−3.25 to 46.24) | 0.09 | 28.63 (0.54 to 56.71) | 0.046 | −4.40 (−57.66 to 48.86) | 0.87 |
Interaction between sex and plasma MMP-9 on CSF Aβ42 | ||||||
Whole cohort | MCI | AD | ||||
β (95% CI) | p value | β (95% CI) | p value | β (95% CI) | p value | |
Sex × free MMP-9 | −24.10 (−55.01 to 6.81) | 0.1 | −44.66 (−85.00 to −4.32) | 0.03 | 15.39 (−36.91 to 67.70) | 0.6 |
Sex × total MMP-9 | −11.00 (−46.16 to 24.15) | 0.5 | −36.66 (−79.55 to 6.22) | 0.09 | 42.49 (−27.17 to 112.14) | 0.2 |