Table 1 Participant demographic and clinical characteristics and differences by sex
From: Sex differences in Alzheimer’s disease: plasma MMP-9 and markers of disease severity
Variable | Men (N=149) | Women (N=89) | Total (N=238) | p value | |
|---|---|---|---|---|---|
Age (years) | 75.69 (7.05) | 72.59 (7.40) | 74.53 (7.33) | 0.001 | |
Diagnosis | Mild cognitive impairment | 95 (63.8%) | 50 (56.2%) | 145 (60.9%) | 0.246 |
Alzheimer’s disease dementia | 54 (36.2%) | 39 (43.8%) | 93 (39.1%) | ||
APOE (ε4-carrier) | 99 (66.4%) | 64 (71.9%) | 163 (68.5%) | 0.380 | |
Education (years) | 16.0 (3.09) | 14.65 (2.92) | 15.50 (3.09) | 0.001 | |
Race | Asian | 2 (1.3%) | 0 | 2 (0.8%) | 0.480 |
Black or African American | 2 (1.3%) | 2 (2.2%) | 4 (1.7%) | ||
White | 145 (97.3%) | 87 (97.8%) | 232 (97.5%) | ||
Diabetes | 10 (6.7%) | 2 (2.3%) | 12 (5.1%) | 0.132 | |
Smoking | 2 (1.3%) | 2 (2.3%) | 4 (1.7%) | 0.591 | |
Hypertension | 96 (64.4%) | 55 (62.5%) | 151 (63.7%) | 0.765 | |
MMSE score | 25.58 (2.59) | 25.26 (2.24) | 25.46 (2.46) | 0.325 | |
Plasma total MMP-9 | 2.36 (0.20) | 2.36 (0.21) | 2.36 (0.20) | 0.898 | |
Plasma free MMP-9 | 2.15 (0.24) | 2.14 (0.23) | 2.14 (0.23) | 0.743 | |
Plasma TIMP-1 | 2.04 (0.11) | 2.02 (0.10) | 2.03 (0.11) | 0.124 | |
CSF t-tau (pg/mL) | 111.87 (55.3) | 134.86 (68.58) | 120.42 (61.45) | 0.005 | |
CSF p-tau181 (pg/mL) | 41.32 (19.20) | 42.75 (17.13) | 41.86 (18.43) | 0.563 | |
CSF Aβ42 (pg/mL) | 134.48 (26.94) | 134.62 (25.86) | 134.53 (26.49) | 0.968 | |