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Table 2 Association of plasma AβO level with flutemetamol PET positivity in logistic regression analysis

From: Plasma amyloid-beta oligomer is related to subjective cognitive decline and brain amyloid status

Independent variable

Adjusted OR

95% confidence interval

p-value

AβO (ratio)

2.04

1.18–4.47

0.04

AβO (concentration [ng/mL])

1.58

1.08–2.58

0.04

  1. In logistic regression models, the outcome variable was the flutemetamol PET positivity (SUVR cutoff ≥ 1.23), and the independent variable was plasma oligomerized Aβ level (ratio or concentration [ng/mL]). The AβO level was rescaled by multiplying 10 by the original value. Models were adjusted for age, sex, years of education, BMI, presence of APOE4, GDS, CDR-SB, the presence of frailty, SNSB-C Z-scores, and history of ever smoking, heavy alcohol drinking, hypertension, diabetes mellitus, cardiovascular diseases, and dyslipidemia
  2. Abbreviations: Aβ, amyloid β; AβO, amyloid-β oligomer; BMI, body mass index; APOE4, apolipoprotein E ε4 allele; CDR-SB, Clinical Dementia Rating-Sum of Boxes; GDS, Geriatric Depression Scale; OR, odds ratio; PET, positron emission tomography; SCD, subjective cognitive decline; SNSB-C, Seoul Neuropsychological Screening Battery-Core; SUVR, standard uptake value ratio
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Alzheimer's Research & Therapy

ISSN: 1758-9193