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Table 2 Overall methodological quality of the included systematic reviews by bibliographical characteristics

From: Methodological quality of systematic reviews on treatments for Alzheimer’s disease: a cross-sectional study

AMSTAR2 rated overall methodological qualityb

Critically lowa

Lowa

Moderatea

Higha

P values

Total

36 (35.3)

48 (47.1)

14 (13.7)

4 (3.9)

-

Cochrane SRs

    

<0.001***

 Yes

2 (20.0)

0 (0)

4 (40.0)

4 (40.0)

 

 No

34 (37.0)

48 (52.2)

10 (10.9)

0 (0)

 

An update of a previous SR

    

0.605

 Yes

5 (35.7)

5 (35.7)

3 (21.4)

1 (7.1)

 

 No

31 (35.2)

43 (48.9)

11 (12.5)

3 (3.4)

 

SRs reporting intervention harms

    

0.188

 Yes

27 (33.8)

36 (45.0)

13 (16.3)

4 (5.0)

 

 No

9 (40.9)

12 (54.5)

1 (4.5)

0 (0)

 

SRs that search for non-English databases

    

0.085

 Yes

15 (29.4)

24 (47.1)

8 (15.7)

4 (7.8)

 

 No

21 (41.2)

24 (47.1)

6 (11.8)

0 (0)

 

Included a PRISMA-like flow diagram

    

0.086

 Yes

30 (34.5)

42 (48.3)

11 (12.6)

4 (4.6)

 

 No

6 (40.0)

6 (40.0)

3 (20.0)

0 (0)

 

Publication year

    

0.652

 2014–2015

15 (41.7)

15 (41.7)

6 (16.7)

0 (0)

 

 2016–2018

8 (27.6)

18 (62.1)

1 (3.4)

2 (6.9)

 

 2019–2021

13 (35.1)

15 (40.5)

7 (18.9)

2 (5.4)

 

Location of the corresponding author

    

0.016*

 Europe

3 (16.7)

7 (38.9)

5 (27.8)

3 (16.7)

 

 America

6 (50.0)

4 (33.3)

1 (8.3)

1 (8.3)

 

 Asia

27 (39.7)

34 (50.0)

7 (10.3)

0 (0)

 

 Oceania

0 (0)

3 (100)

0 (0)

0 (0)

 

 Africa

0 (0)

0 (0)

1 (100)

0 (0)

 

Funding reported by the SR

    

0.240

 No funding

6 (28.6)

11 (52.4)

4 (19.0)

0 (0)

 

 Yes

20 (33.9)

26 (44.1)

9 (15.3)

4 (6.8)

 

 Not reported

10 (45.5)

11 (50.0)

1 (4.5)

0 (0)

 

Types of treatment

    

0.024*

 Non-pharmacological interventions

11 (57.9)

8 (42.1)

0 (0)

0 (0)

 

 Pharmacological treatments

24 (31.2)

36 (46.8)

13 (16.9)

4 (5.2)

 

 Both types

1 (16.7)

4 (66.7)

1 (16.7)

0 (0)

 

Report year span of search

    

0.854

 Not mentioned

2 (66.7)

0 (0)

1 (33.3)

0 (0)

 

 Partially

19 (38.8)

19 (38.8)

7 (14.3)

4 (8.2)

 

 Yes

15 (30.0)

29 (58.0)

6 (12.0)

0 (0)

 

Search terms reported for electronic databases

    

0.023*

 No research term

0 (0)

2 (100)

0 (0)

0 (0)

 

 Topics/free text/keywords/MeSH

26 (42.6)

30 (49.2)

5 (8.2)

0 (0)

 

 Full Boolean

9 (24.3)

15 (40.5)

9 (24.3)

4 (10.8)

 

 Readers are referred elsewhere for full search strategy

1 (50)

1 (50)

0 (0)

0 (0)

 

Language criteria of primary studies

    

0.240

 English only

13 (54.2)

8 (33.3)

3 (12.5)

0 (0)

 

 Language other than English

0 (0)

1 (100)

0 (0)

0 (0)

 

 English and language other than English

14 (26.4)

32 (60.4)

4 (7.5)

3 (5.7)

 

 Not reported

9 (37.5)

7 (29.2)

7 (29.2)

1 (4.2)

 

Methodological quality assessment tools

    

0.001**

 Cochrane Risk of Bias

15 (22.4)

37 (55.2)

11 (16.4)

4 (6.0)

 

 Tools other than Cochrane Risk of Bias

11 (47.8)

10 (43.5)

2 (8.7)

0 (0)

 

 Names of the tools not reported

5 (71.4)

1 (14.3)

1 (14.3)

0 (0)

 

 No quality assessment

5 (100)

0 (0)

0 (0)

0 (0)

 
  1. SR systematic review, PRISMA Preferred Reporting Items for Systematic Reviews and Meta-analysis, MeSH Medical Subject Headings
  2. *p-value of the Kruskal-Wallis test was <0.05, **p-value of the Kruskal-Wallis test was <0.01, ***p-value of the Kruskal-Wallis test was <0.001
  3. aValues are N (% in subgroup)
  4. bOverall methodological quality was an overall rating of methodological quality for each included SR, which was generated based on the assessment results of the 16 AMSTAR2 items. Detailed operational guidance for defining each rank of quality can be found in Additional file 1: Appendix 3