Fig. 2

LPD treatment reversed spatial learning and memory. A No difference in body weight was observed in mice across treatments and genotypes. B LPD treatment dose-dependently decreased the escape latency of APP/PS1 mice in the training trials. C LPD treatment markedly increased the target quadrant time of APP/PS1 mice in the probe trials. D The swimming path of mice in the probe test. E LPD treatment PPARγ-dependently decreased escape latency in the training trials. F There was no difference seen in the swimming speed of mice among treatments and genotypes. G Cotreatment with GW9662 abolished the LPD-mediated increase in the target quadrant time of APP/PS1 mice in the probe trials. H The swimming path of mice in the probe test. I There was no significant change in livers of WT and APP/PS1 mice treated with LPD. Scale bar = 100 μm. Data are expressed as the means ± SD (n = 10 per group) and were analyzed by two-way ANOVA followed by Tukey’s post hoc test. ##, P < 0.01 versus WT; **, P < 0.01 versus APP/PS1 mice. &&, P < 0.01 versus LPD-treated APP/PS1 mice