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Table 2 Association of specific cancer sites with dementia by age, smoking status, and alcohol status

From: Investigating the association between cancer and dementia risk: a longitudinal cohort study

Specific cancer sitesa

Participants with cancer history (N)

ACD

AD

VD

HRb

95% CI

P-value

HRb

95% CI

P-value

HRb

95% CI

P-value

Age <60 years

 Breast

2189

0.73

0.27–1.98

0.538

0.41

0.06–2.97

0.378

3.43

0.78–15.03

0.103

 Colon

254

-

-

-

-

-

-

-

-

-

 Melanoma of skin

350

0.82

0.12–5.87

0.847

1.98

0.28–12.20

0.497

   

 NMSC

1665

0.97

0.43–2.17

0.936

0.77

0.19–3.12

0.715

-

-

-

 Prostate

334

0.67

0.09–4.77

0.686

-

-

-

-

-

-

Age ≥60 years

 Breast

4493

1.04

0.79–1.36

0.787

0.95

0.63–1.41

0.783

0.90

0.46–1.76

0.751

 Colon

767

0.89

049–1.62

0.712

0.76

0.29–2.04

0.590

1.73

0.72–4.19

0.223

 Melanoma of skin

719

1.14

0.64–2.01

0.655

1.26

0.57–2.82

0.567

0.86

0.21–3.44

0.828

 NMSC

5199

0.78

0.61–0.99

0.038

0.79

0.55–1.12

0.184

0.60

0.34–1.06

0.080

 Prostate

2378

0.70

0.49–0.99

0.044

0.58

0.32–1.06

0.077

0.56

0.26–1.19

0.130

Smoking

 Breast

2969

1.24

0.86–1.78

0.243

1.18

0.70–1.99

0.538

1.20

0.52–2.74

0.671

 Colon

556

0.57

0.21–1.52

0.263

0.35

0.05–2.46

0.289

-

-

-

 Melanoma of skin

440

1.51

0.75–3.02

0.248

1.80

0.67–4.81

0.244

0.72

0.10–5.13

0.741

 NMSC

3267

0.67

0.48–0.95

0.025

0.74

0.45–1.23

0.245

0.34

0.13–0.93

0.035

 Prostate

1461

0.73

0.47–1.14

0.164

0.65

0.31–1.38

0.263

0.87

0.41–1.85

0.710

Non-smoking

 Breast

3682

0.83

0.56–1.22

0.339

0.68

0.37–1.23

0.202

0.93

0.38–2.31

0.884

 Colon

459

1.03

0.49–2.18

0.930

1.03

0.33–3.19

0.965

3.64

1.49–8.88

0.004

 Melanoma of skin

627

0.78

0.32–1.87

0.572

1.02

0.33–3.16

0.978

0.80

0.11–5.68

0.819

 NMSC

3577

0.89

0.66–1.22

0.481

0.80

0.50–1.29

0.365

0.80

0.39–1.62

0.527

 Prostate

1233

0.63

0.36–1.09

0.096

0.43

0.16–1.17

0.097

-

-

-

Alcohol

 Breast

6309

1.09

0.83–1.42

0.529

0.92

0.61–1.38

0.682

1.16

0.63–2.15

0.627

 Colon

984

0.83

0.46–1.50

0.536

0.71

0.27–1.90

0.494

1.60

0.66–3.88

0.293

 Melanoma of skin

1023

1.18

0.68–2.04

0.550

1.41

0.67–2.98

0.361

0.82

0.20–3.28

0.776

 NMSC

6618

0.81

0.64–1.02

0.070

0.79

0.56–1.12

0.189

0.51

0.27–0.95

0.034

 Prostate

2639

0.70

0.50–1.00

0.051

0.59

0.32–1.07

0.082

0.58

0.27–1.22

0.149

Non-alcohol

 Breast

362

0.29

0.07–1.18

0.084

0.62

0.14–2.67

0.523

-

-

-

 Colon

37

-

-

-

-

-

-

-

-

-

 Melanoma of skin

46

-

-

-

-

-

-

-

-

-

 NMSC

240

0.43

0.11–1.77

0.244

0.60

0.08–4.38

0.615

1.81

0.42–7.90

0.429

 Prostate

71

0.50

0.07–3.74

0.502

-

-

-

-

-

-

  1. Bold text indicates a p-value less than 0.05, which is statistically significant
  2. − The number of people diagnosed with ACD, AD, or VD in the types of cancer is too small to calculate the HR
  3. Abbreviations: ACD all-cause dementia, AD Alzheimer’s disease, VD vascular dementia, HR hazard ratios, CI confidence interval, NMSC non-melanoma skin cancer
  4. aCommon cancer and more than 1000 people with cancer
  5. bCalculated using Cox proportional hazards modeling, adjusted for age, sex, education, ApoE4, socioeconomic status, BMI, smoking status, alcohol consumption, diabetes, hypertension, heart failure, obesity, and stroke
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Alzheimer's Research & Therapy

ISSN: 1758-9193