From: Investigating the association between cancer and dementia risk: a longitudinal cohort study
Specific cancer sitesa | Participants with cancer history (N) | ACD | AD | VD | ||||||
---|---|---|---|---|---|---|---|---|---|---|
HRb | 95% CI | P-value | HRb | 95% CI | P-value | HRb | 95% CI | P-value | ||
Age <60 years | ||||||||||
Breast | 2189 | 0.73 | 0.27–1.98 | 0.538 | 0.41 | 0.06–2.97 | 0.378 | 3.43 | 0.78–15.03 | 0.103 |
Colon | 254 | - | - | - | - | - | - | - | - | - |
Melanoma of skin | 350 | 0.82 | 0.12–5.87 | 0.847 | 1.98 | 0.28–12.20 | 0.497 | |||
NMSC | 1665 | 0.97 | 0.43–2.17 | 0.936 | 0.77 | 0.19–3.12 | 0.715 | - | - | - |
Prostate | 334 | 0.67 | 0.09–4.77 | 0.686 | - | - | - | - | - | - |
Age ≥60 years | ||||||||||
Breast | 4493 | 1.04 | 0.79–1.36 | 0.787 | 0.95 | 0.63–1.41 | 0.783 | 0.90 | 0.46–1.76 | 0.751 |
Colon | 767 | 0.89 | 049–1.62 | 0.712 | 0.76 | 0.29–2.04 | 0.590 | 1.73 | 0.72–4.19 | 0.223 |
Melanoma of skin | 719 | 1.14 | 0.64–2.01 | 0.655 | 1.26 | 0.57–2.82 | 0.567 | 0.86 | 0.21–3.44 | 0.828 |
NMSC | 5199 | 0.78 | 0.61–0.99 | 0.038 | 0.79 | 0.55–1.12 | 0.184 | 0.60 | 0.34–1.06 | 0.080 |
Prostate | 2378 | 0.70 | 0.49–0.99 | 0.044 | 0.58 | 0.32–1.06 | 0.077 | 0.56 | 0.26–1.19 | 0.130 |
Smoking | ||||||||||
Breast | 2969 | 1.24 | 0.86–1.78 | 0.243 | 1.18 | 0.70–1.99 | 0.538 | 1.20 | 0.52–2.74 | 0.671 |
Colon | 556 | 0.57 | 0.21–1.52 | 0.263 | 0.35 | 0.05–2.46 | 0.289 | - | - | - |
Melanoma of skin | 440 | 1.51 | 0.75–3.02 | 0.248 | 1.80 | 0.67–4.81 | 0.244 | 0.72 | 0.10–5.13 | 0.741 |
NMSC | 3267 | 0.67 | 0.48–0.95 | 0.025 | 0.74 | 0.45–1.23 | 0.245 | 0.34 | 0.13–0.93 | 0.035 |
Prostate | 1461 | 0.73 | 0.47–1.14 | 0.164 | 0.65 | 0.31–1.38 | 0.263 | 0.87 | 0.41–1.85 | 0.710 |
Non-smoking | ||||||||||
Breast | 3682 | 0.83 | 0.56–1.22 | 0.339 | 0.68 | 0.37–1.23 | 0.202 | 0.93 | 0.38–2.31 | 0.884 |
Colon | 459 | 1.03 | 0.49–2.18 | 0.930 | 1.03 | 0.33–3.19 | 0.965 | 3.64 | 1.49–8.88 | 0.004 |
Melanoma of skin | 627 | 0.78 | 0.32–1.87 | 0.572 | 1.02 | 0.33–3.16 | 0.978 | 0.80 | 0.11–5.68 | 0.819 |
NMSC | 3577 | 0.89 | 0.66–1.22 | 0.481 | 0.80 | 0.50–1.29 | 0.365 | 0.80 | 0.39–1.62 | 0.527 |
Prostate | 1233 | 0.63 | 0.36–1.09 | 0.096 | 0.43 | 0.16–1.17 | 0.097 | - | - | - |
Alcohol | ||||||||||
Breast | 6309 | 1.09 | 0.83–1.42 | 0.529 | 0.92 | 0.61–1.38 | 0.682 | 1.16 | 0.63–2.15 | 0.627 |
Colon | 984 | 0.83 | 0.46–1.50 | 0.536 | 0.71 | 0.27–1.90 | 0.494 | 1.60 | 0.66–3.88 | 0.293 |
Melanoma of skin | 1023 | 1.18 | 0.68–2.04 | 0.550 | 1.41 | 0.67–2.98 | 0.361 | 0.82 | 0.20–3.28 | 0.776 |
NMSC | 6618 | 0.81 | 0.64–1.02 | 0.070 | 0.79 | 0.56–1.12 | 0.189 | 0.51 | 0.27–0.95 | 0.034 |
Prostate | 2639 | 0.70 | 0.50–1.00 | 0.051 | 0.59 | 0.32–1.07 | 0.082 | 0.58 | 0.27–1.22 | 0.149 |
Non-alcohol | ||||||||||
Breast | 362 | 0.29 | 0.07–1.18 | 0.084 | 0.62 | 0.14–2.67 | 0.523 | - | - | - |
Colon | 37 | - | - | - | - | - | - | - | - | - |
Melanoma of skin | 46 | - | - | - | - | - | - | - | - | - |
NMSC | 240 | 0.43 | 0.11–1.77 | 0.244 | 0.60 | 0.08–4.38 | 0.615 | 1.81 | 0.42–7.90 | 0.429 |
Prostate | 71 | 0.50 | 0.07–3.74 | 0.502 | - | - | - | - | - | - |