Table 3 Uni- and multivariable clinical correlates of Ln (phosphorylated tau protein)
Number | Separate models, univariable (enter) | Separate models, multivariable (enter) | Separate models, multivariable (backward) | Combined model, multivariable (enter) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
T | p-value | R2 | VIF | T | p-value | VIF | T | p | VIF | T | p-value | ||
Clinical parameters | R2 = 0.63 | R2 = 0.58 | R2 = 0.57 | ||||||||||
Estimated GFR (ml/min/1.73 m2) | 146 | − 6.46 | < 0.001 | 0.23 | 2.28 | − 0.61 | 0.538 | 1.34 | − 2.37 | 0.020 | 1.35 | − 3.00 | 0.003 |
Age (years) | 146 | 6.48 | < 0.001 | 0.23 | 1.84 | 2.86 | 0.005 | 1.25 | 4.60 | < 0.001 | 1.82 | 3.01 | 0.003 |
Urea (mg/dl) | 146 | 6.11 | < 0.001 | 0.21 | 2.24 | 0.61 | 0.538 | ||||||
Left-atrial volume index (ml/m2) | 143 | 5.31 | < 0.001 | 0.17 | 1.93 | 1.99 | 0.049 | 1.09 | 4.57 | < 0.001 | 1.10 | 4.60 | < 0.001 |
Thrombocytes (103/μl) | 145 | − 3.79 | < 0.001 | 0.09 | 1.66 | − 1.45 | 0.149 | ||||||
Creatine kinase (U/l) | 146 | 5.38 | < 0.001 | 0.17 | 1.41 | 4.65 | < 0.001 | 1.04 | 6.49 | < 0.001 | 1.03 | 6.82 | < 0.001 |
Duration of heart failure (years) | 145 | 3.53 | 0.001 | 0.08 | 1.37 | 1.03 | 0.305 | ||||||
Uric acid (mg/dl) | 146 | 3.89 | < 0.001 | 0.10 | 1.68 | 0.51 | 0.607 | ||||||
NT-proBNP (pg/ml) | 146 | 3.66 | < 0.001 | 0.09 | 1.79 | 2.04 | 0.044 | ||||||
Coumadin or novel oral anticoagulant (n/y) | 146 | − 4.06 | < 0.001 | 0.10 | 1.74 | 0.45 | 0.653 | ||||||
Creatine kinase, muscle-brain (U/l) | 146 | 4.63 | < 0.001 | 0.13 | 1.57 | 1.66 | 0.100 | ||||||
Angiotensin-converting enzyme inhibitor (n/y) | 146 | 0.25 | 0.805 | 0.00 | |||||||||
Mean corp. hemoglobin concentr. (g/dl) | 146 | − 2.29 | 0.024 | 0.04 | 1.96 | 0.51 | 0.605 | ||||||
Ferritin (μg/l) | 146 | − 2.65 | 0.009 | 0.05 | 1.36 | − 2.64 | 0.010 | 1.11 | − 3.11 | 0.002 | 1.08 | − 2.28 | 0.024 |
Diuretics (n/y) | 146 | − 3.40 | 0.001 | 0.07 | 1.41 | − 0.13 | 0.894 | ||||||
Basal right ventricular diameter (mm) | 146 | 3.58 | < 0.001 | 0.08 | 1.31 | 1.48 | 0.142 | ||||||
Alanine aminotransferase (U/l) | 146 | − 2.28 | 0.024 | 0.04 | 1.41 | 0.06 | 0.952 | ||||||
MRI parameters | R2 = 0.39 | R2 = 0.39 | |||||||||||
White matter hyperintensity volume (mm3) | 146 | 2.96 | 0.004 | 0.24 | 1.06 | 2.05 | 0.043 | 1.06 | 2.05 | 0.043 | 1.15 | 0.12 | 0.905 |
Cerebral atrophy score (1–8) | 146 | 3.91 | <0.001 | 0.31 | 1.17 | 2.56 | 0.012 | 1.17 | 2.56 | 0.012 | 1.53 | 1.16 | 0.247 |
Hippocampal atrophy score (0–4) | 146 | 3.41 | 0.001 | 0.27 | 1.13 | 2.17 | 0.032 | 1.13 | 2.17 | 0.032 | 1.21 | − 1.09 | 0.278 |
Cognitive domains | R2 = 0.07 | R2 = 0.06 | |||||||||||
Intensity of attention (T-score) | 146 | − 0.86 | 0.389 | 0.01 | |||||||||
Visual/verbal memory (T-score) | 146 | − 3.13 | 0.002 | 0.06 | 1.18 | − 2.48 | 0.014 | 1.00 | − 3.13 | 0.002 | 1.13 | − 1.09 | 0.883 |
Executive functions (T-score) | 146 | − 0.72 | 0.474 | 0.00 | |||||||||
Selectivity of attention (T-score) | 146 | − 2.13 | 0.035 | 0.03 | 1.18 | − 1.04 | 0.302 | ||||||
Working memory (T-score) | 146 | 0.33 | 0.739 | 0.00 | |||||||||
Visual/verbal fluency (T-score) | 146 | 0.17 | 0.863 | 0.00 | |||||||||